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Liu, Feng-Hao; Zhang, En; Qin, Leiyong (, ACM)
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Singh, Sylvia; Wang, Minghui; Gao, Ruixuan; Teng, Peng; Odom, Timothy; Zhang, En; Xu, Hai; Cai, Jianfeng (, Bioorganic & Medicinal Chemistry)
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Su, Ma; Wang, Minghui; Hong, Yuzhu; Nimmagadda, Alekhya; Shen, Ning; Shi, Yan; Gao, Ruixuan; Zhang, En; Cao, Chuanhai; Cai, Jianfeng (, Chemical Communications)We designed a few polymyxin derivatives which exhibit broad-spectrum antimicrobial activity. Lead compound P1 could disrupt bacterial membranes rapidly without developing resistance, inhibit biofilms formed by E. coli , and exhibit excellent in vivo activity in an MRSA-infected thigh burden mouse model.more » « less
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Hill, David E.; Pei, Qing-lan; Zhang, En-xuan; Gage, James R.; Yu, Jin-Quan; Blackmond, Donna G. (, ACS Catalysis)
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